Emerging as a specialized force in targeted anticancer solutions and antibody drug conjugates.
Genome & 바카라사이트, a previously renowned microbiome-focused entity, is now poised to redefine its identity by delving into the realm of innovative targeted anticancer therapeutics. The 바카라사이트's concerted efforts towards technology transfer for a novel targeted anticancer drug signal a transformative shift in its strategic trajectory.
The announcement came to light during a press conference held at Conrad Hotel in Yeouido, Seoul, where Ji-Soo Bae, the CEO of Genome & 바카라사이트, articulated the 바카라사이트's bold ambitions. "Though recognized primarily within the microbiome domain, our 바카라사이트 has quietly been advancing novel targeted anticancer drugs for a significant period," Bae stated. "We stand on the verge of showcasing the tangible outcomes of our steadfast endeavors."
Central to the 바카라사이트's strategic transition are two pioneering pipelines, named 'GENA-104' and 'GENA-111,' both poised for technology transfer. As part of the technology exchange process, Genome & 바카라사이트 is currently in discussions with global pharmaceutical giants to concretize the terms.
GENA-104, one of the 바카라사이트's flagship offerings, takes aim at CNTN4—a previously undiscovered target in the oncology landscape. Miyoung Cha, the Director of the New Drug Research Center at Genome & 바카라사이트, elucidated on the significance of this endeavor. "Within our portfolio, GENA-104 represents a groundbreaking immune oncology agent," Cha explained. "This novel antibody, directed against CNTN4, addresses the pressing challenge of resistance observed in a significant portion of patients receiving conventional anti-PD-(L)1 immune oncology agents."
Further expounding on the mechanism, Director Cha noted, "Our discovery underscores a critical relationship between CNTN4 expression and patient survival rates. Specifically, high CNTN4 expression correlates with lowered survival rates due to the inhibitory interaction between cancer cell CNTN4 and T-cell APP, which impedes T-cell function." Preclinical trials utilizing animal tumor models have demonstrated a correlative relationship between elevated CNTN4 expression and the heightened efficacy of GENA-104, further underscoring its therapeutic potential.
Bolstered by these encouraging prospects, Genome & 바카라사이트 is on track to present the Phase 1 clinical trial proposal (IND) for GENA-104 in the third quarter.
In a parallel avenue of innovation, Genome & 바카라사이트 is pursuing the development of GENA-111, an anticancer Antibody Drug Conjugate (ADC) that has garnered significant attention and investment. Collaborating with Swiss-based Debiopharm since 2021, this endeavor capitalizes on Debiopharm's ADC technology combined with Genome & 바카라사이트's expertise in generating novel targeted antibodies.
GENA-111 zeroes in on CD239, a newly identified target by Genome & 바카라사이트, analogous to the significance of CNTN4. Director Cha elucidated the potential patient population for GENA-111, stating, "CD239's exclusive expression pattern in relation to the ovarian cancer ADC Elahere's target FRα positions it as a viable treatment option for patients unresponsive to Elahere."
CEO Bae emphasized the strategic cohesion between Genome & 바카라사이트's microbiome pipeline and its pioneering anticancer initiatives. "Our proficiency in these two domains emanates from a shared bedrock technology—the Genome Clustering (GNOCLE) genomic analysis platform," Bae underscored. This foundational competency empowers the 바카라사이트 to simultaneously drive innovation in both the microbiome and anticancer sectors.
Notably, CEO Bae provided insight into the progress of the immune oncology treatment 'GEN-001' within the microbiome sphere, assuring that clinical development is proceeding seamlessly. Expectations are set for the release of crucial data at the Gastrointestinal Cancers Symposium (GI ASCO) in January of the upcoming year, a testament to Genome & 바카라사이트's unwavering commitment to transformative medical advancements.
